string fileName = Server.MapPath("~/DownFiles/Data.Txt");
            FileInfo file = new FileInfo(fileName);
            using (FileStream fileStream = file.Open(FileMode.Open))
            {
                StreamReader streamReader = new StreamReader(fileStream);
                while (!streamReader.EndOfStream)
                {
                    string line = streamReader.ReadLine();
                    string[] strs = line.Split(',');
                    //DoYourInsert()
                }
            }